View source for 9uwy


==Cryo-EM structure of the human P2X2 receptor in the ATP-bound desensitised state==
<StructureSection load='9uwy' size='340' side='right'caption='[[9uwy]], [[Resolution|resolution]] 2.48&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9uwy]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9UWY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9UWY FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.48&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9uwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9uwy OCA], [https://pdbe.org/9uwy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9uwy RCSB], [https://www.ebi.ac.uk/pdbsum/9uwy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9uwy ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/P2RX2_HUMAN P2RX2_HUMAN] Rare autosomal dominant non-syndromic sensorineural deafness type DFNA. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/P2RX2_HUMAN P2RX2_HUMAN] ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium (PubMed:10570044, PubMed:31636190). Activation by extracellular ATP induces a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis (By similarity). In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling (PubMed:23345450). Mediates synaptic transmission between neurons and from neurons to smooth muscle (By similarity).[UniProtKB:Q8K3P1]<ref>PMID:10570044</ref> <ref>PMID:23345450</ref> <ref>PMID:31636190</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Cheng XY]]
[[Category: Zhang J]]