View source for 9uyh


==Cryo-EM structure of the G protein-coupled receptor 1 (GPR1) bound to chemerin and beta-arrestin 1 (Conformation 1)==
<StructureSection load='9uyh' size='340' side='right'caption='[[9uyh]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9uyh]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_phage_EcSzw-2 Escherichia phage EcSzw-2] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9UYH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9UYH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9uyh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9uyh OCA], [https://pdbe.org/9uyh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9uyh RCSB], [https://www.ebi.ac.uk/pdbsum/9uyh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9uyh ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RARR2_HUMAN RARR2_HUMAN] Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through activation of the chemokine-like receptor 1 (CMKLR1). Also acts as a ligand for CMKLR2. Can also bind to C-C chemokine receptor-like 2 (CCRL2), but with a lower affinity than it does to CMKLR1 or CMKLR2 (PubMed:27716822). Positively regulates adipocyte differentiation, modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue. Also acts as a pro-inflammatory adipokine, causing an increase in secretion of pro-inflammatory and prodiabetic adipokines, which further impair adipose tissue metabolic function and have negative systemic effects including impaired insulin sensitivity, altered glucose and lipid metabolism, and a decrease in vascular function in other tissues. Can have both pro- and anti-inflammatory properties depending on the modality of enzymatic cleavage by different classes of proteases. Acts as a chemotactic factor for leukocyte populations expressing CMKLR1, particularly immature plasmacytoid dendritic cells, but also immature myeloid DCs, macrophages and natural killer cells. Exerts an anti-inflammatory role by preventing TNF/TNFA-induced VCAM1 expression and monocytes adhesion in vascular endothelial cells. The effect is mediated via inhibiting activation of NF-kappa-B and CRK/p38 through stimulation of AKT1/NOS3 signaling and nitric oxide production. Its dual role in inflammation and metabolism might provide a link between chronic inflammation and obesity, as well as obesity-related disorders such as type 2 diabetes and cardiovascular disease. Exhibits an antimicrobial function in the skin.<ref>PMID:14675762</ref> <ref>PMID:17635925</ref> <ref>PMID:17767914</ref> <ref>PMID:18242188</ref> <ref>PMID:20237162</ref> <ref>PMID:22634313</ref> <ref>PMID:23527010</ref> <ref>PMID:27716822</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia phage EcSzw-2]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Cai H]]
[[Category: He M]]
[[Category: Lin X]]
[[Category: Ma Y]]
[[Category: Shui W]]
[[Category: Wu B]]
[[Category: Xie C]]
[[Category: Yu J]]
[[Category: Zhang B]]
[[Category: Zhao L]]
[[Category: Zhao Q]]
[[Category: Zhu Y]]