View source for 9uyn


==Cryo-EM structure of the G protein-coupled receptor 1 (GPR1) bound to beta-arrestin 1 in ligand-free state==
<StructureSection load='9uyn' size='340' side='right'caption='[[9uyn]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9uyn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_phage_EcSzw-2 Escherichia phage EcSzw-2] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9UYN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9UYN FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PAM:PALMITOLEIC+ACID'>PAM</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9uyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9uyn OCA], [https://pdbe.org/9uyn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9uyn RCSB], [https://www.ebi.ac.uk/pdbsum/9uyn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9uyn ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/V2R_HUMAN V2R_HUMAN] Nephrogenic syndrome of inappropriate antidiuresis;Inappropriate antidiuretic hormone secretion syndrome;Nephrogenic diabetes insipidus. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/CML2_HUMAN CML2_HUMAN] Receptor for chemoattractant adipokine chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation and energy homesotasis (PubMed:18165312, PubMed:27716822). Signals mainly via beta-arrestin pathway. Binding of RARRES2 activates weakly G proteins, calcium mobilization and MAPK1/MAPK3 (ERK1/2) phosphorylation too (PubMed:27716822). Acts also as a receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity).[UniProtKB:Q8K087]<ref>PMID:18165312</ref> <ref>PMID:27716822</ref>   (Microbial infection) Coreceptor for HIV-1.<ref>PMID:10233994</ref> [https://www.uniprot.org/uniprot/V2R_HUMAN V2R_HUMAN] Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption.<ref>PMID:19440390</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia phage EcSzw-2]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Cai H]]
[[Category: He M]]
[[Category: Lin X]]
[[Category: Ma Y]]
[[Category: Shui W]]
[[Category: Wu B]]
[[Category: Xie C]]
[[Category: Yu J]]
[[Category: Zhang B]]
[[Category: Zhao L]]
[[Category: Zhao Q]]
[[Category: Zhu Y]]