View source for 9v46


==Coupling of polymerase-nucleoprotein-RNA in an influenza virus mini ribonucleoprotein complex==
<StructureSection load='9v46' size='340' side='right'caption='[[9v46]], [[Resolution|resolution]] 3.62&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9v46]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Victoria/3/1975(H3N2)) Influenza A virus (A/Victoria/3/1975(H3N2))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9V46 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9V46 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.62&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9v46 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9v46 OCA], [https://pdbe.org/9v46 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9v46 RCSB], [https://www.ebi.ac.uk/pdbsum/9v46 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9v46 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/H9XIJ2_I75A3 H9XIJ2_I75A3] Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits. The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching. It consists in the hijacking and cleavage of host capped pre-mRNAs. These short capped RNAs are then used as primers for viral mRNAs. The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity.[HAMAP-Rule:MF_04063]
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</StructureSection>
[[Category: Large Structures]]
[[Category: Kang H]]
[[Category: Li M]]
[[Category: Lin Y]]
[[Category: Liu Y]]
[[Category: Lou Z]]
[[Category: Rao Z]]
[[Category: Yang Y]]
[[Category: Zhang L]]