View source for 9v5k


==Crystal Structure of Nur77 LBD in complex with N-(2'-(methyl(pentyl)amino)-[4,4'-bipyridin]-2-yl)cinnamamide==
<StructureSection load='9v5k' size='340' side='right'caption='[[9v5k]], [[Resolution|resolution]] 2.37&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9v5k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9V5K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9V5K FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.37&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1D6A:(~{E})-~{N}-[4-[2-[methyl(pentyl)amino]pyridin-4-yl]pyridin-2-yl]-3-phenyl-prop-2-enamide'>A1D6A</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9v5k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9v5k OCA], [https://pdbe.org/9v5k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9v5k RCSB], [https://www.ebi.ac.uk/pdbsum/9v5k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9v5k ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NR4A1_HUMAN NR4A1_HUMAN] Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2.<ref>PMID:15466594</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Chen XQ]]
[[Category: Hong WB]]
[[Category: Lin TW]]