View source for 9van


==Cryo-EM structure of human full length KICSTOR complex (state 2)==
<StructureSection load='9van' size='340' side='right'caption='[[9van]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9van]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9VAN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9VAN FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9van FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9van OCA], [https://pdbe.org/9van PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9van RCSB], [https://www.ebi.ac.uk/pdbsum/9van PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9van ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/SZT2_HUMAN SZT2_HUMAN] Non-specific early-onset epileptic encephalopathy. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/SZT2_HUMAN SZT2_HUMAN] As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose (PubMed:28199306, PubMed:28199315). May play a role in the cellular response to oxidative stress (By similarity).[UniProtKB:A2A9C3]<ref>PMID:28199306</ref> <ref>PMID:28199315</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Su M-Y]]