View source for 9vhx


==Keratin 14 120 - 144 peptide fragment (R125S)==
<StructureSection load='9vhx' size='340' side='right'caption='[[9vhx]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9vhx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9VHX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9VHX FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR,  models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9vhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9vhx OCA], [https://pdbe.org/9vhx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9vhx RCSB], [https://www.ebi.ac.uk/pdbsum/9vhx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9vhx ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/K1C14_HUMAN K1C14_HUMAN] Epidermolysis bullosa simplex, Dowling-Meara type;Localized epidermolysis bullosa simplex;Dermatopathia pigmentosa reticularis;Naegeli-Franceschetti-Jadassohn syndrome;Epidermolysis bullosa simplex with mottled pigmentation;Generalized epidermolysis bullosa simplex, non-Dowling-Meara type;KRT14-related epidermolysis bullosa simplex. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/K1C14_HUMAN K1C14_HUMAN] The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro.<ref>PMID:11724817</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Li HW]]
[[Category: Li ZY]]
[[Category: Wang CX]]
[[Category: Zhang WB]]