View source for 9vlv


==Crystal structure of bovine Adenosine Deaminase in complex with EHNA==
<StructureSection load='9vlv' size='340' side='right'caption='[[9vlv]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9vlv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9VLV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9VLV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CYS:CYSTEINE'>CYS</scene>, <scene name='pdbligand=EH9:(2S,3R)-3-(6-AMINO-9H-PURIN-9-YL)NONAN-2-OL'>EH9</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9vlv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9vlv OCA], [https://pdbe.org/9vlv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9vlv RCSB], [https://www.ebi.ac.uk/pdbsum/9vlv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9vlv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ADA_BOVIN ADA_BOVIN] Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion (By similarity).
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</StructureSection>
[[Category: Bos taurus]]
[[Category: Large Structures]]
[[Category: Bijpuria S]]
[[Category: Gu W]]
[[Category: Kulkarni C]]
[[Category: Pawar P]]
[[Category: Valles G]]