View source for 9vo8


==Co-crystal structure of HPK1 in complex with compound 15==
<StructureSection load='9vo8' size='340' side='right'caption='[[9vo8]], [[Resolution|resolution]] 2.46&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9vo8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9VO8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9VO8 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.46&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1EUJ:~{N}-[6-[[5-chloranyl-2-[[3-[(dimethylamino)methyl]-1-methyl-indol-5-yl]amino]pyrimidin-4-yl]amino]quinoxalin-5-yl]methanesulfonamide'>A1EUJ</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9vo8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9vo8 OCA], [https://pdbe.org/9vo8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9vo8 RCSB], [https://www.ebi.ac.uk/pdbsum/9vo8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9vo8 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/M4K1_HUMAN M4K1_HUMAN] Serine/threonine-protein kinase, which may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation. Able to autophosphorylate.<ref>PMID:24362026</ref> <ref>PMID:8824585</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Yan XE]]
[[Category: Yun CH]]
[[Category: Zhang YD]]