View source for 9vsk


==Crystal structure of anthocyanin 4'-O-methyltransferase from Vitis vinifera L.==
<StructureSection load='9vsk' size='340' side='right'caption='[[9vsk]], [[Resolution|resolution]] 2.78&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9vsk]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Vitis_vinifera Vitis vinifera]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9VSK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9VSK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.78&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9vsk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9vsk OCA], [https://pdbe.org/9vsk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9vsk RCSB], [https://www.ebi.ac.uk/pdbsum/9vsk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9vsk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FAOMT_VITVI FAOMT_VITVI] Mediates O-methylation of anthocyanins. Anthocyanins are major pigments in grapes: at ripening initiation in red grapevine berries, the exocarp turns color from green to red and then to purple due to the accumulation and extent of methylation of anthocyanins. Catalyzes both 3' and 5' O-methylation of anthocyanins, with a preference for glycosylated substrates. Active on both anthocyanins and flavonols in vitro. Most active with delphinidin 3-glucoside but also acts on cyanidin 3-glucoside, cyanidin, myricetin, quercetin and quercetin 3-glucoside. Not able to methylate flavan type skeletons with chiral centers, such as catechins or dihydroquercetin.<ref>PMID:19525322</ref> <ref>PMID:20580386</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Vitis vinifera]]
[[Category: Lin W]]