View source for 9vv6


==The structure of ITN bound OXGR1==
<StructureSection load='9vv6' size='340' side='right'caption='[[9vv6]], [[Resolution|resolution]] 2.62&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9vv6]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli], [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9VV6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9VV6 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.62&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ITN:2-METHYLIDENEBUTANEDIOIC+ACID'>ITN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9vv6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9vv6 OCA], [https://pdbe.org/9vv6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9vv6 RCSB], [https://www.ebi.ac.uk/pdbsum/9vv6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9vv6 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/OXGR1_HUMAN OXGR1_HUMAN] The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.[https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.[https://www.uniprot.org/uniprot/OXGR1_HUMAN OXGR1_HUMAN] G protein-coupled receptor for dicarboxylates and amino dicarboxylates (PubMed:15141213, PubMed:36571463, PubMed:36919698). Receptor for itaconate, a metabolite produced by myeloid lineages (PubMed:36919698). In the respiratory epithelium, couples the binding of itaconate to the activation of GNA11 and downstream intracellular Ca(2+) release, leading to mucocilliary clearance of airborne pathogens (PubMed:36919698). Receptor for leukotriene E4 (LTE4) produced by mast cells upon allergic inflammation. Binds with high affinity to LTE4 and elicits mucin release from pulmonary epithelium in response to airborne fungi allergens. Regulates mucin-producing goblet cell homeostasis (By similarity). Receptor for alpha-ketoglutarate produced by proximal tubule renal cells upon metabolic alkalosis. In an intrarenal paracrine signaling pathway, binds alpha-ketoglutarate and drives transepithelial salt reabsorption and bicarbonate secretion by SLC26A4/pendrin-positive intercalated cells (By similarity) (PubMed:15141213).[UniProtKB:Q6IYF8]<ref>PMID:15141213</ref> <ref>PMID:36571463</ref> <ref>PMID:36919698</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli K-12]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Chen ZY]]
[[Category: Liang EY]]
[[Category: Ma TS]]
[[Category: Su Q]]
[[Category: Tang XF]]