View source for 9vvg


==Cryo-EM structure of the erlin1/2 complex purified using GDN and CHS==
<StructureSection load='9vvg' size='340' side='right'caption='[[9vvg]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9vvg]] is a 26 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9VVG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9VVG FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9vvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9vvg OCA], [https://pdbe.org/9vvg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9vvg RCSB], [https://www.ebi.ac.uk/pdbsum/9vvg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9vvg ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/ERLN1_HUMAN ERLN1_HUMAN] Autosomal recessive spastic paraplegia type 62. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/ERLN1_HUMAN ERLN1_HUMAN] Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway (PubMed:37683630). Binds cholesterol and may promote ER retention of the SCAP-SREBF complex (PubMed:24217618).<ref>PMID:19240031</ref> <ref>PMID:24217618</ref> <ref>PMID:37683630</ref>   (Microbial infection) Required early in hepatitis C virus (HCV) infection to initiate RNA replication, and later in the infection to support infectious virus production.<ref>PMID:31810281</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Gao N]]
[[Category: Xu Z]]
[[Category: Yan L]]