View source for 9vwp


==human OSM in complex with Nb3.43==
<StructureSection load='9vwp' size='340' side='right'caption='[[9vwp]], [[Resolution|resolution]] 3.03&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9vwp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Vicugna_pacos Vicugna pacos]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9VWP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9VWP FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.03&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9vwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9vwp OCA], [https://pdbe.org/9vwp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9vwp RCSB], [https://www.ebi.ac.uk/pdbsum/9vwp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9vwp ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ONCM_HUMAN ONCM_HUMAN] Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity).<ref>PMID:1542792</ref> <ref>PMID:1542793</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Vicugna pacos]]
[[Category: Wen Y]]