View source for 9vwz


==Local refinement region of HPV45 in complex with antibody A16E6==
<StructureSection load='9vwz' size='340' side='right'caption='[[9vwz]], [[Resolution|resolution]] 4.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9vwz]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Human_papillomavirus_45 Human papillomavirus 45]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9VWZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9VWZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9vwz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9vwz OCA], [https://pdbe.org/9vwz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9vwz RCSB], [https://www.ebi.ac.uk/pdbsum/9vwz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9vwz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/VL1_HPV45 VL1_HPV45] Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.[HAMAP-Rule:MF_04002]
__TOC__
</StructureSection>
[[Category: Human papillomavirus 45]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Jiang Y]]
[[Category: Li S]]
[[Category: Sun H]]
[[Category: Zheng Q]]