View source for 9vxw


==Cryo-EM structure of hAQP11 in LMNG==
<StructureSection load='9vxw' size='340' side='right'caption='[[9vxw]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9vxw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aequorea_victoria Aequorea victoria] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9VXW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9VXW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D10:DECANE'>D10</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9vxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9vxw OCA], [https://pdbe.org/9vxw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9vxw RCSB], [https://www.ebi.ac.uk/pdbsum/9vxw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9vxw ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/AQP11_HUMAN AQP11_HUMAN] Channel protein that facilitates the transport of water, glycerol and hydrogen peroxide across membrane of cell or organelles guaranteeing intracellular homeostasis in several organes like liver, kidney and brain (PubMed:24845055, PubMed:24918044, PubMed:31546170). In situation of stress, participates in endoplasmic reticulum (ER) homeostasis by regulating redox homeostasis through the transport of hydrogen peroxide across the endoplasmic reticulum membrane thereby regulating the oxidative stress through the NADPH oxidase 2 pathway (PubMed:31546170). Plays a role by maintaining an environment suitable for translation or protein foldings in the ER lumen namely by participating in the PKD1 glycosylation processing resulting in regulation of PKD1 membrane trafficking thereby preventing the accumulation of unfolding protein in ER (By similarity). Plays a role in the proximal tubule function by regulating its endosomal acidification (By similarity). May play a role in postnatal kidney development (By similarity).[UniProtKB:Q8BHH1]<ref>PMID:24845055</ref> <ref>PMID:24918044</ref> <ref>PMID:31546170</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Aequorea victoria]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Fujiyoshi Y]]
[[Category: Kamegawa A]]
[[Category: Nishikawa K]]
[[Category: Suzuki S]]
[[Category: Kozai D]]