View source for 9w40


==Structure of adenosine A2BR with an agonist MRS3997==
<StructureSection load='9w40' size='340' side='right'caption='[[9w40]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9w40]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9W40 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9W40 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1EUU:(2~{R},3~{R},4~{S},5~{R})-2-[6-azanyl-2-[2-(6-bromanyl-1~{H}-indol-3-yl)ethoxy]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol'>A1EUU</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9w40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9w40 OCA], [https://pdbe.org/9w40 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9w40 RCSB], [https://www.ebi.ac.uk/pdbsum/9w40 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9w40 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GBB1_HUMAN GBB1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.<ref>PMID:18611381</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Chang H]]
[[Category: Chen Y]]
[[Category: Gao ZG]]
[[Category: Hua T]]
[[Category: Jacobson K]]
[[Category: Pavan M]]
[[Category: Song GJ]]
[[Category: Weng Y]]