View source for 9w4l


==Cryo-EM structure of inhibitor M353-0039 bound urea transporter A2.==
<StructureSection load='9w4l' size='340' side='right'caption='[[9w4l]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9w4l]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9W4L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9W4L FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1EU9:~{N}-[2-[[2-methyl-5-(4-methyl-1,3-thiazol-2-yl)thiophen-3-yl]amino]-2-oxidanylidene-ethyl]furan-2-carboxamide'>A1EU9</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9w4l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9w4l OCA], [https://pdbe.org/9w4l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9w4l RCSB], [https://www.ebi.ac.uk/pdbsum/9w4l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9w4l ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/UT2_HUMAN UT2_HUMAN] Mediates the transport of urea driven by a concentration gradient across the cell membrane of the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism.<ref>PMID:11502588</ref> <ref>PMID:17702749</ref>   Mediates the transport of urea driven by a concentration gradient across the cell membrane of the kidney inner medullary collecting duct which is critical to the urinary concentrating mechanism.<ref>PMID:8647271</ref> <ref>PMID:8997401</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Huang S]]
[[Category: Sun J]]