View source for 9w78


==Rhinolophus cornutus Bat ACE2 Dimer in Complex with Two Rc-o319 Sarbecovirus Spike RBDs.==
<StructureSection load='9w78' size='340' side='right'caption='[[9w78]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9w78]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhinolophus_cornutus Rhinolophus cornutus] and [https://en.wikipedia.org/wiki/Sarbecovirus Sarbecovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9W78 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9W78 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9w78 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9w78 OCA], [https://pdbe.org/9w78 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9w78 RCSB], [https://www.ebi.ac.uk/pdbsum/9w78 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9w78 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A7R7AIC6_9CHIR A0A7R7AIC6_9CHIR] Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis. Converts angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II. Also removes the C-terminal residue from three other vasoactive peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin. Also cleaves other biological peptides, such as apelins, casomorphins and dynorphin A. Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in intestine, regulating trafficking, expression on the cell surface, and its catalytic activity.[ARBA:ARBA00056418]
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</StructureSection>
[[Category: Large Structures]]
[[Category: Rhinolophus cornutus]]
[[Category: Sarbecovirus]]
[[Category: Hang Y]]
[[Category: Li ZM]]
[[Category: Li ZX]]
[[Category: Wang J]]
[[Category: Xiong X]]