View source for 9wgh


==Solution structure of human VAPB MSP domain==
<StructureSection load='9wgh' size='340' side='right'caption='[[9wgh]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9wgh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9WGH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9WGH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR,  models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9wgh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9wgh OCA], [https://pdbe.org/9wgh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9wgh RCSB], [https://www.ebi.ac.uk/pdbsum/9wgh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9wgh ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/VAPB_HUMAN VAPB_HUMAN] Adult-onset proximal spinal muscular atrophy, autosomal dominant;Amyotrophic lateral sclerosis. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/VAPB_HUMAN VAPB_HUMAN] Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation.<ref>PMID:16891305</ref> <ref>PMID:20940299</ref> <ref>PMID:22131369</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Enomoto-Kusano M]]
[[Category: Fujiwara T]]
[[Category: Furuita K]]
[[Category: Kobayashi N]]
[[Category: Kodama ST]]
[[Category: Kojima C]]
[[Category: Komuro R]]
[[Category: Miyanoiri Y]]
[[Category: Togawa W]]