View source for 9wgk


==Crystal structure of OcuKAI2d2 from Orobanche cumana bound to Dehydrocostus Lactone==
<StructureSection load='9wgk' size='340' side='right'caption='[[9wgk]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9wgk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Orobanche_cernua_var._cumana Orobanche cernua var. cumana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9WGK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9WGK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1MBP:(3~{a}~{R},6~{a}~{S},9~{a}~{R},9~{b}~{S})-3,6,9-trimethylidene-3~{a},4,5,6~{a},7,8,9~{a},9~{b}-octahydroazuleno[4,5-b]furan-2-one'>A1MBP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9wgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9wgk OCA], [https://pdbe.org/9wgk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9wgk RCSB], [https://www.ebi.ac.uk/pdbsum/9wgk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9wgk ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Seed germination of the parasitic plant Orobanche cumana is induced by host-derived strigolactones and dehydrocostus lactone. We show that the KAI2d2 receptor perceives both ligands through distinct modes of interaction. Triazole urea compounds covalently inhibit KAI2d receptors, suppressing germination without affecting sunflower growth.

Orobanche cumana KAI2d2 mediates perception of dehydrocostus lactone and strigolactones and is inhibited by triazole ureas.,Shahul Hameed UF, Jamil M, Zarban R, Saito Y, Alashoor K, Balakrishna A, Asami T, Arold ST, Al-Babili S Plant Commun. 2026 May 7:101889. doi: 10.1016/j.xplc.2026.101889. PMID:42104616<ref>PMID:42104616</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 9wgk" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Orobanche cernua var. cumana]]
[[Category: Arold ST]]
[[Category: Hameed UFS]]