View source for 9wgr


==E. coli SufE with deletion of TQHL (residues 112-115)==
<StructureSection load='9wgr' size='340' side='right'caption='[[9wgr]], [[Resolution|resolution]] 1.53&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9wgr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9WGR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9WGR FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.53&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9wgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9wgr OCA], [https://pdbe.org/9wgr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9wgr RCSB], [https://www.ebi.ac.uk/pdbsum/9wgr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9wgr ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SUFE_ECOLI SUFE_ECOLI] Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process. Together with the SufBCD complex, it thereby enhances up to 50-fold, the cysteine desulfurase activity of SufS. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Does not affect the selenocysteine lyase activity of SufS.<ref>PMID:12876288</ref> <ref>PMID:12941942</ref> <ref>PMID:14644425</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Fujishiro T]]
[[Category: Sakurai R]]