View source for 9wjs


==Tti1-Telo2 complex==
<StructureSection load='9wjs' size='340' side='right'caption='[[9wjs]], [[Resolution|resolution]] 3.83&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9wjs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9WJS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9WJS FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.83&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9wjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9wjs OCA], [https://pdbe.org/9wjs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9wjs RCSB], [https://www.ebi.ac.uk/pdbsum/9wjs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9wjs ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TELO2_HUMAN TELO2_HUMAN] Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation.<ref>PMID:12670948</ref> <ref>PMID:20810650</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Qin Y]]
[[Category: Wang P]]
[[Category: Xu G]]