View source for 9wmq


==The cryo-electron microscopy complex structure of PCV3 VLPs and antibody 2B5==
<StructureSection load='9wmq' size='340' side='right'caption='[[9wmq]], [[Resolution|resolution]] 1.73&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9wmq]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus Mus] and [https://en.wikipedia.org/wiki/Porcine_circovirus_3 Porcine circovirus 3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9WMQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9WMQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 1.73&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9wmq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9wmq OCA], [https://pdbe.org/9wmq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9wmq RCSB], [https://www.ebi.ac.uk/pdbsum/9wmq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9wmq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A6B9EZK0_9CIRC A0A6B9EZK0_9CIRC] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Porcine circovirus type 3 (PCV3) is an emerging swine pathogen associated with reproductive failure and systemic inflammation, but vaccines for related PCV2 provide limited cross-protection. Here, we determine high-resolution cryo-EM structures of PCV3 capsid protein assembled into virus-like particles (VLPs) and of PCV3 VLPs bound to the PCV3-specific antibody 2B5. The structures reveal differences from PCV2 in surface loops and define a conserved 2B5 epitope mainly involving the BC, EF and HI loops, providing a structural basis for PCV3-specific recognition. PCV3 VLPs induce sustained antibody responses in mice and pigs. In a pig challenge model, VLP immunization prevents viremia and viral replication in lungs and lymph nodes, as measured by quantitative PCR and in situ hybridization, with protection maintained for at least five months after boosting. These findings support PCV3 VLPs as a vaccine candidate against PCV3 infection.

Structural basis and immunogenic efficacy of porcine circovirus type 3 virus-like particle.,Su J, Tong X, Jiang Y, Li Y, Yan H, Liu Y, Wang Y, Su X, Sun Z, Wang M, Xia N, Bostina M, Li S, Pang W, Zheng Q, Tian K Nat Commun. 2026 Jun 16. doi: 10.1038/s41467-026-74388-z. PMID:42303972<ref>PMID:42303972</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 9wmq" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus]]
[[Category: Porcine circovirus 3]]
[[Category: Jiang Y]]
[[Category: Li S]]
[[Category: Su J]]
[[Category: Zheng Q]]