View source for 9wnn


==Human Pin1 (Peptidyl-prolyl cis-trans isomerase) catalytic domain in complex with a covalent inhibitor==
<StructureSection load='9wnn' size='340' side='right'caption='[[9wnn]], [[Resolution|resolution]] 2.12&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9wnn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9WNN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9WNN FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.12&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1ERA:3-[bis(oxidanyl)methyl]pentane-1,1,3,5,5-pentol'>A1ERA</scene>, <scene name='pdbligand=A1EX9:~{N}-(1-benzothiophen-2-ylmethyl)-~{N}-[(1~{S})-3,3-bis(fluoranyl)cyclopentyl]ethanamide'>A1EX9</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9wnn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9wnn OCA], [https://pdbe.org/9wnn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9wnn RCSB], [https://www.ebi.ac.uk/pdbsum/9wnn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9wnn ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PIN1_HUMAN PIN1_HUMAN] Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.<ref>PMID:15664191</ref> <ref>PMID:16644721</ref> <ref>PMID:21497122</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Wang XY]]
[[Category: Xu BL]]
[[Category: Zhang DP]]
[[Category: Zhou J]]