View source for 9wok


==Crystal structure of Human FN3K bound with TDI-017058-FA-1==
<StructureSection load='9wok' size='340' side='right'caption='[[9wok]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9wok]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9WOK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9WOK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1MBZ:3-(1-methylpiperidin-4-yl)-~{N}-[(3~{R},4~{R})-1-[(3-methyl-[1,2]thiazolo[5,4-b]pyridin-5-yl)carbonyl]-3-oxidanyl-piperidin-4-yl]benzamide'>A1MBZ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9wok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9wok OCA], [https://pdbe.org/9wok PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9wok RCSB], [https://www.ebi.ac.uk/pdbsum/9wok PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9wok ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FN3K_HUMAN FN3K_HUMAN] Fructosamine-3-kinase involved in protein deglycation by mediating phosphorylation of fructoselysine residues on glycated proteins, to generate fructoselysine-3 phosphate (PubMed:11016445, PubMed:11522682, PubMed:11975663). Fructoselysine-3 phosphate adducts are unstable and decompose under physiological conditions (PubMed:11522682, PubMed:11975663). Involved in intracellular deglycation in erythrocytes (PubMed:11975663). Involved in the response to oxidative stress by mediating deglycation of NFE2L2/NRF2, glycation impairing NFE2L2/NRF2 function (By similarity). Also able to phosphorylate psicosamines and ribulosamines (PubMed:14633848).[UniProtKB:Q9ER35]<ref>PMID:11016445</ref> <ref>PMID:11522682</ref> <ref>PMID:11975663</ref> <ref>PMID:14633848</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Huang M]]
[[Category: Huggins D]]
[[Category: Kargman S]]
[[Category: Miller M]]
[[Category: Qian D]]