View source for 9wvh


==Crystal structure of TONSL UBL domain==
<StructureSection load='9wvh' size='340' side='right'caption='[[9wvh]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9wvh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9WVH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9WVH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.96&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9wvh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9wvh OCA], [https://pdbe.org/9wvh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9wvh RCSB], [https://www.ebi.ac.uk/pdbsum/9wvh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9wvh ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TONSL_HUMAN TONSL_HUMAN] Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. Within the complex, may act as a scaffold.<ref>PMID:21055983</ref> <ref>PMID:21055984</ref> <ref>PMID:21055985</ref> <ref>PMID:7738005</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Karmakar A]]
[[Category: Roy S]]