View source for 9wxv


==Cryo-EM structure of TMEM63A-digitonin-cholesterol==
<StructureSection load='9wxv' size='340' side='right'caption='[[9wxv]], [[Resolution|resolution]] 4.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9wxv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9WXV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9WXV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9wxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9wxv OCA], [https://pdbe.org/9wxv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9wxv RCSB], [https://www.ebi.ac.uk/pdbsum/9wxv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9wxv ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/TM63A_HUMAN TM63A_HUMAN] The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/TM63A_HUMAN TM63A_HUMAN] Mechanosensitive cation channel with low conductance and high activation threshold (PubMed:30382938, PubMed:31587869, PubMed:37543036). In contrast to TMEM63B, does not show phospholipid scramblase activity (PubMed:39716028). Acts as a regulator of lysosomal morphology by mediating lysosomal mechanosensitivity (By similarity). Important for the baby's first breath and respiration throughout life (PubMed:38127458). Upon lung inflation conducts cation currents in alveolar type 1 and 2 cells triggering lamellar body exocytosis and surfactant secretion into airspace (PubMed:38127458). Also acts as an osmosensitive cation channel preferentially activated by hypotonic stress (By similarity).[UniProtKB:Q91YT8]<ref>PMID:30382938</ref> <ref>PMID:31587869</ref> <ref>PMID:37543036</ref> <ref>PMID:38127458</ref> <ref>PMID:39716028</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Cheng D]]
[[Category: Corry B]]
[[Category: Cox DC]]
[[Category: Han Y]]
[[Category: Ju L]]
[[Category: Lin Y]]
[[Category: Wang H]]
[[Category: Zhang Y]]
[[Category: Zhou Z]]