View source for 9xd5


==Crimean-Congo hemorrhagic fever virus RNA polymerase in complex with the 5' vRNA==
<StructureSection load='9xd5' size='340' side='right'caption='[[9xd5]], [[Resolution|resolution]] 2.72&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9xd5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Crimean-Congo_hemorrhagic_fever_virus_strain_IbAr10200 Crimean-Congo hemorrhagic fever virus strain IbAr10200]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9XD5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9XD5 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.72&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9xd5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9xd5 OCA], [https://pdbe.org/9xd5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9xd5 RCSB], [https://www.ebi.ac.uk/pdbsum/9xd5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9xd5 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/L_CCHFI L_CCHFI] Displays RNA-directed RNA polymerase, deubiquitinating and deISGylase activities. RNA-dependent RNA polymerase is responsible for replication and transcription of the viral RNA genome. The deubiquitinating activity cleaves both ubiquitinated and ISGylated products and may therefore regulate ubiquitin and ISG15 dependent innate immunity.
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</StructureSection>
[[Category: Crimean-Congo hemorrhagic fever virus strain IbAr10200]]
[[Category: Large Structures]]
[[Category: Chang T]]
[[Category: Gui J]]
[[Category: Pan H]]
[[Category: Xiong X]]
[[Category: Xue L]]