View source for 9xuj


==Crystal structure of MPXV poxin==
<StructureSection load='9xuj' size='340' side='right'caption='[[9xuj]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9xuj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Monkeypox_virus Monkeypox virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9XUJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9XUJ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9xuj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9xuj OCA], [https://pdbe.org/9xuj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9xuj RCSB], [https://www.ebi.ac.uk/pdbsum/9xuj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9xuj ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/POXIN_MONPV POXIN_MONPV] Nuclease that is responsible for viral evasion of host cGAS-STING innate immunity. Cleaves 2',3'-cGAMP which is produced by host cGAS following recognition of cytosolic DNA and blocks the subsequent 2',3'-cGAMP-mediated activation of TMEM173/STING, which normally spreads to adjacent cells and activates the interferon and NF-kappa-B immune responses.
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</StructureSection>
[[Category: Large Structures]]
[[Category: Monkeypox virus]]
[[Category: Huang YX]]
[[Category: Zhao BY]]