View source for 9xvd


==Crystal structure of NFIC homodimer bound to DNA==
<StructureSection load='9xvd' size='340' side='right'caption='[[9xvd]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9xvd]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9XVD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9XVD FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9xvd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9xvd OCA], [https://pdbe.org/9xvd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9xvd RCSB], [https://www.ebi.ac.uk/pdbsum/9xvd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9xvd ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NFIC_HUMAN NFIC_HUMAN] Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Liu K]]
[[Category: Min JR]]
[[Category: Pan SL]]