View source for 9xxt


==Cryo-EM structure of lysophosphatidylserine (18:0)-bound GPR174-Gs complex==
<StructureSection load='9xxt' size='340' side='right'caption='[[9xxt]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9xxt]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9XXT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9XXT FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1E1Q:(2~{S})-2-azanyl-3-[[(2~{R})-3-octadecanoyloxy-2-oxidanyl-propoxy]-oxidanyl-phosphoryl]oxy-propanoic+acid'>A1E1Q</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9xxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9xxt OCA], [https://pdbe.org/9xxt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9xxt RCSB], [https://www.ebi.ac.uk/pdbsum/9xxt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9xxt ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GP174_HUMAN GP174_HUMAN] G-protein-coupled receptor of lysophosphatidylserine (LysoPS) that plays different roles in immune response (PubMed:36823105). Plays a negative role in regulatory T-cell accumulation and homeostasis. Under inflammatory conditions where LysoPS production increases, contributes to the down-regulation of regulatory T-cell activity to favor effector response. Mediates the suppression of IL-2 production in activated T-lymphocytes leading to inhibition of growth, proliferation and differentiation of T-cells. Mechanistically, acts via G(s)-containing heterotrimeric G proteins to trigger elevated cyclic AMP levels and protein kinase A/PKA activity, which may in turn act to antagonize proximal TCR signaling. Plays an important role in the initial period of sepsis through the regulation of macrophage polarization and pro- and anti-inflammatory cytokine secretions. Upon testosterone treatment, acts as a receptor for CCL21 and subsequently triggers through G(q)-alpha and G(12)/G(13) proteins a calcium flux leading to chemotactic effects on activated B-cells. Signals via GNA13 and PKA to promote CD86 up-regulation by follicular B-cells.[UniProtKB:Q3U507]<ref>PMID:36823105</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Dong Y-J]]
[[Category: Mao C-Y]]
[[Category: Qi H]]
[[Category: Shen D-D]]
[[Category: Wang W-W]]
[[Category: Xi K]]
[[Category: Xue J-H]]
[[Category: Zang S-K]]
[[Category: Zhang Y]]
[[Category: Zhang Y-Z]]
[[Category: Zhao R-Z]]