View source for 9xzy


==DEPDC5 dimer (tandem DEPDC5) focused map==
<StructureSection load='9xzy' size='340' side='right'caption='[[9xzy]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9xzy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9XZY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9XZY FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9xzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9xzy OCA], [https://pdbe.org/9xzy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9xzy RCSB], [https://www.ebi.ac.uk/pdbsum/9xzy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9xzy ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/DEPD5_HUMAN DEPD5_HUMAN] Rolandic epilepsy;Autosomal dominant nocturnal frontal lobe epilepsy;Autosomal dominant epilepsy with auditory features;Familial focal epilepsy with variable foci. The disease is caused by mutations affecting the gene represented in this entry.  Inactivating mutations and truncating deletions in the genes encoding GATOR1 proteins, including DEPDC5, are detected in glioblastoma and ovarian tumors and are associated with loss of heterozygosity events. Inactivation of GATOR1 proteins promotes constitutive localization of mTORC1 to the lysosomal membrane and blocks mTORC1 inactivation following amino acid withdrawal (PubMed:23723238).<ref>PMID:23723238</ref> 
== Function ==
[https://www.uniprot.org/uniprot/DEPD5_HUMAN DEPD5_HUMAN] As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway.<ref>PMID:23723238</ref> <ref>PMID:25457612</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Bayly-Jones C]]
[[Category: Chang YG]]
[[Category: Ellisdon AM]]
[[Category: Lupton CJ]]