View source for 9y5j


==Cryo-EM structure of apo full-length mouse TRPML2 channel in lipid nanodisc, closed III==
<StructureSection load='9y5j' size='340' side='right'caption='[[9y5j]], [[Resolution|resolution]] 3.09&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9y5j]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9Y5J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9Y5J FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.09&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9y5j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9y5j OCA], [https://pdbe.org/9y5j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9y5j RCSB], [https://www.ebi.ac.uk/pdbsum/9y5j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9y5j ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MCLN2_MOUSE MCLN2_MOUSE] Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as a Ca(2+)-permeable cation channel with inwardly rectifying activity (PubMed:19763610). May activate ARF6 and be involved in the trafficking of GPI-anchored cargo proteins to the cell surface via the ARF6-regulated recycling pathway (By similarity). May play a role in immune processes. In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells (PubMed:17050035). In the innate immune response, may play a role in the regulation of chemokine secretion and macrophage migration (PubMed:26432893). Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events. Also functions as a Fe(2+) permeable channel (PubMed:18794901).[UniProtKB:Q8IZK6]<ref>PMID:17050035</ref> <ref>PMID:18794901</ref> <ref>PMID:19763610</ref> <ref>PMID:22753890</ref> <ref>PMID:26432893</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Park S]]
[[Category: Yang J]]