View source for 9ygu


==Flagella filament structure in H. pylori composed of flagellin FlaA==
<StructureSection load='9ygu' size='340' side='right'caption='[[9ygu]], [[Resolution|resolution]] 2.88&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9ygu]] is a 33 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori_B128 Helicobacter pylori B128]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9YGU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9YGU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.88&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P8E:(2~{S},4~{S},5~{S},6~{S})-5-azanyl-6-[(1~{S},2~{S})-1-azanyl-2-oxidanyl-propyl]-2,4-bis(oxidanyl)oxane-2-carboxylic+acid'>P8E</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ygu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ygu OCA], [https://pdbe.org/9ygu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ygu RCSB], [https://www.ebi.ac.uk/pdbsum/9ygu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ygu ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The bacterial flagellum is a complex nanomachine essential for motility, colonization, and invasion in diverse species. Helicobacter pylori has evolved elaborate sheathed flagella that enable migration through the highly viscous gastric mucus layer to reach its colonization niche on the gastric epithelium, yet the molecular basis for these unique adaptations has remained elusive. Here, we use in situ single-particle cryo-electron microscopy to determine near-atomic structures of the flagellar filament within the membranous sheath of H. pylori. The major flagellin FlaA constitutes the bulk of the filament, whereas the minor flagellin FlaB contributes critically to the hook-proximal region. Both FlaA and FlaB form a conserved core surrounded by variable surface-exposed domains. Our structures further reveal that pseudaminic acid glycans decorate these domains, where they mediate inter- and intra-subunit contacts that stabilize the filament and confer a negatively charged surface. Together, these findings support a model in which the filament rotates independently of the membranous sheath to drive H. pylori motility and provide a molecular framework for understanding how the sheathed flagellum enables colonization and persistence within the gastric niche.

Assembly and glycosylation of Helicobacter pylori sheathed flagella.,Kumar R, Tachiyama S, Yu H, Heydari S, Guo J, Botting JM, Guo W, Hoover TR, Liu J PNAS Nexus. 2026 Jan 20;5(2):pgag011. doi: 10.1093/pnasnexus/pgag011. eCollection , 2026 Feb. PMID:41659214<ref>PMID:41659214</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 9ygu" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Helicobacter pylori B128]]
[[Category: Large Structures]]
[[Category: Kumar R]]
[[Category: Liu J]]
[[Category: Tachiyama S]]
[[Category: Yu H]]