View source for 9yic


==Crystal structure of human IL-17A in complex with Compound 1==
<StructureSection load='9yic' size='340' side='right'caption='[[9yic]], [[Resolution|resolution]] 3.15&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9yic]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9YIC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9YIC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.15&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1CXF:(3~{S})-~{N}-[[3-[[(1~{S})-1-cyclohexyl-2-oxidanylidene-2-phenylazanyl-ethyl]carbamoyl]phenyl]methyl]-2,2-dimethyl-thiomorpholine-3-carboxamide'>A1CXF</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9yic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9yic OCA], [https://pdbe.org/9yic PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9yic RCSB], [https://www.ebi.ac.uk/pdbsum/9yic PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9yic ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IL17_HUMAN IL17_HUMAN] Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts.
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Armstrong AA]]
[[Category: Luo J]]
[[Category: Milligan CM]]