View source for 9yr4


==Cryo-EM structure of human Tom70 in complex with Hsp90 C-terminal EEVD peptide==
<StructureSection load='9yr4' size='340' side='right'caption='[[9yr4]], [[Resolution|resolution]] 3.64&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9yr4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9YR4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9YR4 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.64&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9yr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9yr4 OCA], [https://pdbe.org/9yr4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9yr4 RCSB], [https://www.ebi.ac.uk/pdbsum/9yr4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9yr4 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TOM70_HUMAN TOM70_HUMAN] Acts as a receptor of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) (PubMed:12526792). Recognizes and mediates the translocation of mitochondrial preproteins from the cytosol into the mitochondria in a chaperone dependent manner (PubMed:12526792, PubMed:35025629). Mediates TBK1 and IRF3 activation induced by MAVS in response to Sendai virus infection and promotes host antiviral responses during virus infection (PubMed:20628368, PubMed:25609812, PubMed:32728199). Upon Sendai virus infection, recruits HSP90AA1:IRF3:BAX in mitochondrion and the complex induces apoptosis (PubMed:25609812).<ref>PMID:12526792</ref> <ref>PMID:20628368</ref> <ref>PMID:25609812</ref> <ref>PMID:32728199</ref> <ref>PMID:35025629</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Cho JH]]
[[Category: Sherer N]]
[[Category: Yadav GP]]