View source for 9ysn


==Human DCTPP1 bound to a Class I inhibitor==
<StructureSection load='9ysn' size='340' side='right'caption='[[9ysn]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9ysn]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9YSN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9YSN FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1C0E:2-[[7-(4-cyclohexylpiperazin-1-yl)-4-nitro-2,1,3-benzoxadiazol-5-yl]amino]ethanol'>A1C0E</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ysn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ysn OCA], [https://pdbe.org/9ysn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ysn RCSB], [https://www.ebi.ac.uk/pdbsum/9ysn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ysn ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DCTP1_HUMAN DCTP1_HUMAN] Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.<ref>PMID:24467396</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Berger JM]]
[[Category: Hauk G]]