View source for 9ysp


==Human DCTPP1 bound to a Class III inhibitor==
<StructureSection load='9ysp' size='340' side='right'caption='[[9ysp]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9ysp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9YSP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9YSP FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1C0C:4-(4-chlorophenyl)-6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylsulfanyl-pyrimidine-5-carbonitrile'>A1C0C</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ysp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ysp OCA], [https://pdbe.org/9ysp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ysp RCSB], [https://www.ebi.ac.uk/pdbsum/9ysp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ysp ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DCTP1_HUMAN DCTP1_HUMAN] Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.<ref>PMID:24467396</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Berger JM]]
[[Category: Hauk G]]