View source for 9yy4


==Importin a2 in complex with Lone Star virus non-structural S (NSs) NLS peptide==
<StructureSection load='9yy4' size='340' side='right'caption='[[9yy4]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9yy4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lone_Star_virus Lone Star virus] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9YY4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9YY4 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9yy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9yy4 OCA], [https://pdbe.org/9yy4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9yy4 RCSB], [https://www.ebi.ac.uk/pdbsum/9yy4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9yy4 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IMA1_MOUSE IMA1_MOUSE] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
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</StructureSection>
[[Category: Large Structures]]
[[Category: Lone Star virus]]
[[Category: Mus musculus]]
[[Category: Forwood JK]]
[[Category: Hawker JE]]