View source for 9z4w


==Cryo-EM structure of rabbit major vault protein complex==
<StructureSection load='9z4w' size='340' side='right'caption='[[9z4w]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9z4w]] is a 78 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9Z4W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9Z4W FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9z4w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9z4w OCA], [https://pdbe.org/9z4w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9z4w RCSB], [https://www.ebi.ac.uk/pdbsum/9z4w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9z4w ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/G1SVM1_RABIT G1SVM1_RABIT] Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.[ARBA:ARBA00025300]
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</StructureSection>
[[Category: Large Structures]]
[[Category: Oryctolagus cuniculus]]
[[Category: Clarke OB]]
[[Category: Li H]]