View source for 9za2


==cryoEM structure of COMMD-like protein S4Y171 octamer==
<StructureSection load='9za2' size='340' side='right'caption='[[9za2]], [[Resolution|resolution]] 4.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9za2]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Sorangium_cellulosum_So0157-2 Sorangium cellulosum So0157-2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9ZA2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9ZA2 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.7&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9za2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9za2 OCA], [https://pdbe.org/9za2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9za2 RCSB], [https://www.ebi.ac.uk/pdbsum/9za2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9za2 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/S4XVP2_SORCE S4XVP2_SORCE] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The ten eukaryotic COMMD proteins are core components of the Commander complex, with central roles in endosomal membrane trafficking and signalling. Each protein has an alpha-helical N-terminal (HN) domain with a C-terminal copper metabolism gene MURR1 (COMM) domain. These ten family members assemble into a heterodecameric ring composed of five specific heterodimers. In this work we have combined structural homology searches with genome-wide predicted structures to identify ancestral COMMD-like proteins that exist as single genes in Bacteria and Archaea. Although there is limited sequence similarity to the eukaryotic proteins the bacterial and archaeal COMMD-like proteins are predicted to form homomeric ring-shaped assemblies like their eukaryotic counterparts. Our biophysical studies, crystal and cryo-EM structures confirm COMMD-like proteins readily form homooligomeric rings composed of eight or ten subunits assembled from core dimeric building blocks and inter-dimer interactions that are analogous to the heterodecameric core structure of the eukaryotic Commander complex. Phylogenetic analyses using amino acid sequences and FoldSeek structural alphabet (3Di) infer that the closest identified relatives to the eukaryotic COMMD proteins are found in Myxococcota bacteria. These findings indicate that COMMD genes emerged early in eukaryotic evolution through multiple rounds of duplication from a single ancestral gene likely acquired from bacteria.

The prokaryotic origins of the COMMD protein family involved in eukaryotic membrane trafficking.,Liu M, Moody ERR, Blades F, Puente-Lelievre C, Chen KE, Stephens EJ, Michie KA, Cater RJ, Williams TA, Collins BM, Healy MD Nat Commun. 2026 May 29. doi: 10.1038/s41467-026-73536-9. PMID:42215467<ref>PMID:42215467</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 9za2" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Sorangium cellulosum So0157-2]]
[[Category: Blades F]]
[[Category: Cater RJ]]
[[Category: Collins BM]]
[[Category: Healy MD]]
[[Category: Liu M]]