View source for 9zaw


==HMG-CoA synthase 1 (HMGCS1) bound to inhibitor compound CNP7==
<StructureSection load='9zaw' size='340' side='right'caption='[[9zaw]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9zaw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9ZAW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9ZAW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.29&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1C1C:(3S)-1-[(Z)-iminomethyl]-N-({(1P)-3-[(prop-2-yn-1-yl)carbamoyl][1,1-biphenyl]-3-yl}methyl)pyrrolidine-3-carboxamide'>A1C1C</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9zaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9zaw OCA], [https://pdbe.org/9zaw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9zaw RCSB], [https://www.ebi.ac.uk/pdbsum/9zaw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9zaw ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HMCS1_HUMAN HMCS1_HUMAN] This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: An H]]
[[Category: Sen S]]
[[Category: Sun L]]
[[Category: De la Cruz MJ]]