View source for 9zcu


==Human TRPM8 V915Y fully-swapped, closed, ligand-free structure resolved in GDN==
<StructureSection load='9zcu' size='340' side='right'caption='[[9zcu]], [[Resolution|resolution]] 2.86&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9zcu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9ZCU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9ZCU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.86&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9zcu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9zcu OCA], [https://pdbe.org/9zcu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9zcu RCSB], [https://www.ebi.ac.uk/pdbsum/9zcu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9zcu ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TRPM8_HUMAN TRPM8_HUMAN] Non-selective ion channel permeable to monovalent and divalent cations, including Na(+), K(+), and Ca(2+), with higher permeability for Ca(2+). Activated by multiple factors, such as temperature, voltage, pressure, and changes in osmolality. Activated by cool temperatures (<23-28 degrees Celsius) and by chemical ligands evoking a sensation of coolness, such as menthol and icilin therefore plays a central role in the detection of environmental cold temperatures (PubMed:15306801, PubMed:15852009, PubMed:16174775, PubMed:25559186, PubMed:37857704). TRPM8 is a voltage-dependent channel; its activation by cold or chemical ligands shifts its voltage thresholds towards physiological membrane potentials, leading to the opening of the channel (PubMed:15306801). In addition to its critical role in temperature sensing, regulates basal tear secretion by sensing evaporation-induced cooling and changes in osmolality (By similarity). May plays a role in prostate cancer cell migration (PubMed:16174775, PubMed:25559186).[UniProtKB:Q8R4D5]<ref>PMID:15306801</ref> <ref>PMID:15852009</ref> <ref>PMID:16174775</ref> <ref>PMID:25559186</ref> <ref>PMID:37857704</ref>   Negatively regulates menthol- and cold-induced channel activity by stabilizing the closed state of the channel.<ref>PMID:22128173</ref>   Negatively regulates menthol- and cold-induced channel activity by stabilizing the closed state of the channel.<ref>PMID:22128173</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Cheng Y]]
[[Category: Choi KY]]
[[Category: Julius D]]
[[Category: Lin X]]