View source for 9zgf


==The complex of HSV-1 proteins UL9 and ICP8 with forked DNA==
<StructureSection load='9zgf' size='340' side='right'caption='[[9zgf]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9zgf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1_strain_17 Human alphaherpesvirus 1 strain 17]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9ZGF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9ZGF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9zgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9zgf OCA], [https://pdbe.org/9zgf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9zgf RCSB], [https://www.ebi.ac.uk/pdbsum/9zgf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9zgf ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DNBI_HHV11 DNBI_HHV11] Plays several crucial roles in viral infection. Participates in the opening of the viral DNA origin to initiate replication by interacting with the origin-binding protein UL9. May disrupt loops, hairpins and other secondary structures present on ssDNA to reduce and eliminate pausing of viral DNA polymerase at specific sites during elongation. Promotes viral DNA recombination by performing strand-transfer, characterized by the ability to transfer a DNA strand from a linear duplex to a complementary single-stranded DNA circle. Can also catalyze the renaturation of complementary single strands.<ref>PMID:15078942</ref> <ref>PMID:7961904</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Human alphaherpesvirus 1 strain 17]]
[[Category: Large Structures]]
[[Category: Babayeva ND]]
[[Category: Baranovskiy AG]]
[[Category: Morstadt LM]]
[[Category: Romero EE]]
[[Category: Tahirov TH]]