View source for 9zmz


==Crystal structure of the human Commd4 HN domain in a domain swapped conformation==
<StructureSection load='9zmz' size='340' side='right'caption='[[9zmz]], [[Resolution|resolution]] 2.12&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9zmz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9ZMZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9ZMZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.12&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9zmz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9zmz OCA], [https://pdbe.org/9zmz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9zmz RCSB], [https://www.ebi.ac.uk/pdbsum/9zmz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9zmz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/COMD4_HUMAN COMD4_HUMAN] Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (PubMed:37172566, PubMed:38459129). May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Down-regulates activation of NF-kappa-B (PubMed:23637203).<ref>PMID:15799966</ref> <ref>PMID:37172566</ref> <ref>PMID:38459129</ref> <ref>PMID:21778237</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Collins BM]]
[[Category: Hall R]]
[[Category: Healy MD]]
[[Category: Liu M]]