View source for 9zou


==OXA-23-JDB/PQ-1-219, 40 min complex==
<StructureSection load='9zou' size='340' side='right'caption='[[9zou]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9zou]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baumannii Acinetobacter baumannii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9ZOU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9ZOU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1C3I:(5~{S})-5-[(2~{S},3~{R})-1,3-bis(oxidanyl)-1-oxidanylidene-butan-2-yl]-3-[[(3~{R})-2,3-dihydroazet-3-yl]sulfanyl]-5-methyl-pyrrole-2-carboxylic+acid'>A1C3I</scene>, <scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9zou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9zou OCA], [https://pdbe.org/9zou PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9zou RCSB], [https://www.ebi.ac.uk/pdbsum/9zou PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9zou ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BLO23_ACIBA BLO23_ACIBA] Class D beta-lactamase which confers resistance to the beta-lactam antibiotics, including ampicillin, and carbapenems such as imipenem and meropenem (PubMed:18725452, PubMed:20194701, PubMed:24012371, PubMed:30530607, PubMed:35420470). Acts via hydrolysis of the beta-lactam ring (PubMed:23877677, PubMed:24012371, PubMed:30530607, PubMed:35420470). Has penicillin-, cephalosporin- and carbapenem-hydrolyzing activities, but lacks ceftazidime-hydrolyzing activity (PubMed:23877677, PubMed:24012371, PubMed:30530607, PubMed:35420470).<ref>PMID:18725452</ref> <ref>PMID:20194701</ref> <ref>PMID:23877677</ref> <ref>PMID:24012371</ref> <ref>PMID:30530607</ref> <ref>PMID:35420470</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Acinetobacter baumannii]]
[[Category: Large Structures]]
[[Category: Maggiolo AM]]
[[Category: Smith CA]]
[[Category: Toth M]]
[[Category: Vakulenko SB]]