View source for 9zp4


==E. coli RNA polymerase elongation complex containing the unnatural dZ:PTP base pair in a trigger-loop-closed conformation==
<StructureSection load='9zp4' size='340' side='right'caption='[[9zp4]], [[Resolution|resolution]] 2.42&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9zp4]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9ZP4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9ZP4 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.42&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1C5A:[[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-4-oxidanylidene-imidazo[1,2-a][1,3,5]triazin-8-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]+phosphono+hydrogen+phosphate'>A1C5A</scene>, <scene name='pdbligand=DZ:N-(3,5-DIBROMO-4-HYDROXYPHENYL)-2,6-DIMETHYLBENZAMIDE'>DZ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9zp4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9zp4 OCA], [https://pdbe.org/9zp4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9zp4 RCSB], [https://www.ebi.ac.uk/pdbsum/9zp4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9zp4 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RPOA_ECOLI RPOA_ECOLI] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit plays an important role in subunit assembly since its dimerization is the first step in the sequential assembly of subunits to form the holoenzyme.[HAMAP-Rule:MF_00059]
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Benner SA]]
[[Category: Li Q]]
[[Category: Wang D]]