View source for 9zq7


==Autoinhibited P-Rex2==
<StructureSection load='9zq7' size='340' side='right'caption='[[9zq7]], [[Resolution|resolution]] 5.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9zq7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9ZQ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9ZQ7 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 5.2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9zq7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9zq7 OCA], [https://pdbe.org/9zq7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9zq7 RCSB], [https://www.ebi.ac.uk/pdbsum/9zq7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9zq7 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PREX2_HUMAN PREX2_HUMAN] Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase.<ref>PMID:15304342</ref> <ref>PMID:15304343</ref> <ref>PMID:15897194</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Anderson LK]]
[[Category: Cash JN]]