View source for A Disintegrin And Metalloproteinase

<StructureSection load='' size='350' side='right' scene='43/436101/Cv/2' caption='A Disintegrin And Metalloproteinase complex with sulfate [[2ao7]]'>

== Function ==

[[A Disintegrin And Metalloproteinase]] (ADAM)  are peptidases which cleave off extracellular portions of transmembrane proteins.  ADAM family members are numbered.<br />
* '''ADAM10''' cleaves ephrin.<br />
* '''ADAM13''' details are in [[Molecular Playground/ADAM13]].<br />
* '''ADAM17''' (TACE or TNF-α converting enzyme) processes the tumor necrosis factor-α.<br />
* '''ADAM33''' is implicated in asthma.<br />
* '''ADAMTS''' is ADAM with thrombospondin motifs<ref>PMID:15554875</ref>. <br />
* '''ADAMTS1''' has anti-angionenic activity<ref>PMID:10811842</ref>. <br />
* '''ADAMTS4''' and '''ADAMTS5''' are involved in the degradation of aggrecan.<br />
*  '''ADAMTS13''' cleaves [[Von Willebrand Factor]] involved in blood clotting<ref>PMID:18762209</ref>.
== Disease ==

ADAM inhibitors are used in anti-cancer therapy.  '''ADAM10''' is a therapeutic target for cancer and inflammation <ref>PMID:19601831</ref>.  '''ADAM17''' is a therapeutic target for multiple diseases <ref>PMID:19601834</ref>. '''ADAM33''' is implicated in asthma.    '''ADAM33''' is a therapeutic target for asthma <ref>PMID:38396994</ref>.  '''ADAMTS4''' is involved  in various CNS pathologies<ref>PMID:28084617</ref>.

== 3D Structures of A Disintegrin And Metalloproteinase ==
[[A Disintegrin And Metalloproteinase 3D structures]]

</StructureSection>

== References ==
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