View source for Aciclovir

<StructureSection load='' size='340' side='right' caption='Aciclovir' scene='10/1012895/Cv/2'>
Aciclovir (ACV), also known as acyclovir,<ref name="a3">Kevin ES. [https://deutschemedz.de/aciclovir "The Aciclovir"] (in German). Kevin. Retrieved 25 May 2017.</ref> is an antiviral medication.<ref name="a4">de Clercq E, Field HJ (5 October 2005). "Antiviral prodrugs – the development of successful prodrug strategies for antiviral chemotherapy". [https://en.wikipedia.org/wiki/British_Journal_of_Pharmacology British Journal of Pharmacology.] Vol. 147, no. 1. Wiley-Blackwell (published January 2006). pp. 1–11.</ref> It is primarily used for the treatment of herpes simplex virus infections, chickenpox, and shingles.<ref name="a5">[https://www.drugs.com/monograph/acyclovir.html "Acyclovir".] The American Society of Health-System Pharmacists. Archived from the original on 2015-01-05. Retrieved Jan 1, 2015.</ref> Other uses include prevention of cytomegalovirus infections following transplant and severe complications of Epstein–Barr virus infection.<ref name="a5">[https://www.drugs.com/monograph/acyclovir.html "Acyclovir".] The American Society of Health-System Pharmacists. Archived from the original on 2015-01-05. Retrieved Jan 1, 2015.</ref><ref name="a6">PMID:20739216</ref> See also [https://en.wikipedia.org/wiki/Aciclovir Aciclovir].

Aciclovir is converted by viral [[thymidine kinase]] to aciclovir monophosphate, which is then converted by host cell kinases to aciclovir triphosphate (ACV-TP, also known as aciclo-GTP).<ref name="a28">[https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2009-PI-00595-3 "PRODUCT INFORMATION NAME OF THE DRUG OZVIR TABLETS"] (PDF). TGA eBusiness Services. Ranbaxy Australia Pty Ltd. 26 August 2011. Archived from the original on 20 August 2016. Retrieved 6 February 2014.</ref> ACV-TP is a very potent inhibitor of viral DNA replication (see [[DNA Replication, Transcription and Translation]]). ACV-TP competitively inhibits and inactivates the viral [[DNA polymerase]].<ref name="a41">["https://gskpro.com/content/dam/global/hcpportal/en_US/Prescribing_Information/Valtrex/pdf/VALTREX-PI-PIL.PDF VALTREX (valacyclovir hydrochloride) Caplets -GSKSource".] gsksource.com. Retrieved 2019-08-02.</ref> Its monophosphate form also incorporates into the viral DNA, resulting in chain termination.<ref name="a28">[https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2009-PI-00595-3 "PRODUCT INFORMATION NAME OF THE DRUG OZVIR TABLETS"] (PDF). TGA eBusiness Services. Ranbaxy Australia Pty Ltd. 26 August 2011. Archived from the original on 20 August 2016. Retrieved 6 February 2014.</ref><ref name="a42">[https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=12ea5042-8ea6-4ee9-a734-684a73edb373] "Acyclovir (acyclovir) Capsule Acyclovir (acyclovir) Tablet [Genpharm Inc.]". DailyMed. Genpharm Inc. November 2006. Archived from the original on 21 February 2014. Retrieved 5 February 2014.</ref><ref name="a43">[https://web.archive.org/web/20140222201708/http://www.medicines.org.uk/EMC/medicine/23721/SPC/Aciclovir+Tablets+BP+400mg "Aciclovir Tablets BP 400mg - Summary of Product Characteristics (SPC)". electronic Medicines Compendium. Actavis UK Ltd. 20 August 2012. Archived from the original on 22 February 2014. Retrieved 5 February 2014.]</ref>

<scene name='10/1012895/Cv/3'>Herpes simplex virus type-1 thymidine kinase in complex with Acyclovir</scene> ([[2ki5]]).

<scene name='10/1012895/Binding_site/1'>Aciclovir binding site</scene>.
</StructureSection>
== References ==
<references/>